Cortical metabolic alterations induced by genetic redox deregulation in GCLM KO mice and the protective effect of N- acetylcysteine treatment: Relevance for schizophrenia
نویسندگان
چکیده
J. M. Duarte, A. Kulak, K. Q. Do, and R. Gruetter Laboratory for functional and metabolic imaging, Center for Biomedical Imaging, Ecole Polytechnique, Lausanne, Vaud, Switzerland, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Vaud, Switzerland, Center for Psychiatric Neuroscience, Univ. Hosp. Lausanne, Switzerland, Department of Radiology, Universities of Lausanne and Geneva, Lausanne, Switzerland
منابع مشابه
N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development.
BACKGROUND Glutathione (GSH) is the major cellular redox-regulator and antioxidant. Redox-imbalance due to genetically impaired GSH synthesis is among the risk factors for schizophrenia. Here we used a mouse model with chronic GSH deficit induced by knockout (KO) of the key GSH-synthesizing enzyme, glutamate-cysteine ligase modulatory subunit (GCLM). METHODS With high-resolution magnetic reso...
متن کاملDevelopmental in vivo 1H NMR spectroscopy at 14.1 T in mice with genetic redox dysregulation: an animal model with relevance to schizophrenia
Introduction: Glutathione (GSH), a major redox regulator and antioxidant, is decreased in cerebrospinal fluid and prefrontal cortex of schizophrenia patients [1]. The genes of the key GSH-synthesizing enzyme, glutamate-cysteine ligase catalytic (GCLC) and modifier (GCLM) subunits, are associated with schizophrenia, suggesting that the deficit in GSH synthesis is of genetic origin [2]. GCLM knoc...
متن کاملEarly-life insults impair parvalbumin interneurons via oxidative stress: reversal by N-acetylcysteine.
BACKGROUND A hallmark of the pathophysiology of schizophrenia is a dysfunction of parvalbumin-expressing fast-spiking interneurons, which are essential for the coordination of neuronal synchrony during sensory and cognitive processing. Oxidative stress as observed in schizophrenia affects parvalbumin interneurons. However, it is unknown whether the deleterious effect of oxidative stress is part...
متن کاملProtective effect of N-acetylcysteine on Dipentyl phthalate (DPeP) induced cognitive dysfunction and brain oxidative stress in mice
Background: Dipentyl phthalate (DPeP) is a plasticizer compound commonly used in polyvinylchloride plastic to increase their softness and flexibility. They are not bound covalently to the plastic polymers and can therefore leach out into the environment, and have been shown to adversely affect the health of humans and animals. Methods: We investigated the effect of DPeP on the various cognitive...
متن کاملProtective Effect of N-Acetyl Cysteine on Chlorpyrifos-Induced Testicular Toxicity in Mice
Objective Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. The present study investigated the protective effect of N- Acetyl Cysteine (NAC), a potent antioxidant against toxicity effect of CPF in male mice. MaterialsAndMethods in an e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010